The immune checkpoint pathophysiology of depression and chronic fatigue syndrome due to preeclampsia: focus on sCD80 and sCTLA-4

The findings underscore that PE and depression, anxiety, and chronic fatigue symptoms due to PE are accompanied by activation of the immune-inflammatory response system. More specifically, disbalances among soluble checkpoint molecules seem to be involved in the pathophysiology of hypertension and neuropsychiatric symptoms due to PE.

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Publication Details

Journal
Acta Neuropsychiatrica
Published
2025-01-01
DOI
https://doi.org/10.1017/neu.2025.10
Primary Topic
Pregnancy and preeclampsia studies
Type
article
Field-Weighted Citation Impact
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article

The immune checkpoint pathophysiology of depression and chronic fatigue syndrome due to preeclampsia: focus on sCD80 and sCTLA-4

Mengqi Niu, Michael H. J. Maes, Niaz Albarzinji, Shatha Rouf Moustafa et al.
Acta Neuropsychiatrica
Pregnancy and preeclampsia studies
article

The immune checkpoint pathophysiology of depression and chronic fatigue syndrome due to preeclampsia: focus on sCD80 and sCTLA-4

Mengqi Niu, Michael H. J. Maes, Niaz Albarzinji, Shatha Rouf Moustafa, Hussein Kadhem Al‐Hakeim, Jangir Sami Omar, Naz Hawree Taher, Bayar Aram, Mohammed Salam Sulaiman
article en

Abstract

The findings underscore that PE and depression, anxiety, and chronic fatigue symptoms due to PE are accompanied by activation of the immune-inflammatory response system. More specifically, disbalances among soluble checkpoint molecules seem to be involved in the pathophysiology of hypertension and neuropsychiatric symptoms due to PE.

Acta NeuropsychiatricaVol. 37
University of Electronic Science and Technology of China (CN), Chulalongkorn University (TH), Hawler Medical University (IQ), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Medical University Plovdiv (BG), Kyung Hee University (KR), University of Kufa (IQ)
Good health and well-being
Openalex Percentile: Top 92%
Pregnancy and preeclampsia studies
DOIOpen Access PDFOpenAlex
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The immune checkpoint pathophysiology of depression and chronic fatigue syndrome due to preeclampsia: focus on sCD80 and sCTLA-4 — Mengqi Niu, Michael H. J. Maes, et al. · Acta Neuropsychiatrica (2025) | TGRS Research Map | TGRS