Metronidazole response profiles of Gardnerella species are congruent with phylogenetic and comparative genomic analyses
This study provides comparative genomic and phylogenetic evidence for eleven distinct genospecies within the genus Gardnerella vaginalis spp., and identifies genospecies-specific responses to metronidazole, the first-line treatment for BV. A companion molecular diagnostic assay was developed that is capable of identifying essentially all highly metronidazole-resistant strains that phylogenetically cluster together within the GV genospecies, which is informative for antibiotic treatment options.
Authors
- Sharon L. Hillier
- Shirley Barrera
- Katherine A. Innamorati
- Bhaswati Sen
- Adam C. Retchless (ORCID: https://orcid.org/0000-0001-7185-591X)
- Rachel L. Ehrlich
- Evan Powell
- Joshua Chang Mell (ORCID: https://orcid.org/0000-0003-0222-5636)
- Garth D. Ehrlich (ORCID: https://orcid.org/0000-0003-0341-8771)
- ALLAN S. GORDON (ORCID: https://orcid.org/0000-0002-2058-7289)
- Azad Ahmed
- Sergey V. Balashov
- Joshua P. Earl (ORCID: https://orcid.org/0000-0002-9830-5173)
- Josephine Aiyeku
Institutions
- University of Pittsburgh (US)
- Allegheny-Singer Research Institute (US)
- Magee-Womens Hospital (US)
- University of Pittsburgh Medical Center (US)
- Drexel University (US)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1186/s13073-025-01446-4
- Citations
- 5
- Primary Topic
- Microbial infections and disease research
- Type
- article
- Field-Weighted Citation Impact
- 5.92