Highly diastereoselective synthesis of annulated 2‐acyl‐2,3‐dihydrofurans
Abstract A simple and convenient method to synthesize annulated 2‐acyl‐2,3‐dihydrofuran derivatives by Michael addition‐alkylation reaction of α‐bromochalcones and 5,5‐dimethylcyclohexane‐1,3‐dione is described. This transformation was well compatible with various α‐bromochalcones, and the corresponding 2‐acyl‐2,3‐dihydrofurans were obtained in yields of up to 98%.
Authors
- Jun Yang (ORCID: https://orcid.org/0000-0002-4480-5340)
- Lin Li (ORCID: https://orcid.org/0000-0002-3614-903X)
- Jinxiang Feng
- Guizhou Yue (ORCID: https://orcid.org/0000-0001-7811-0531)
- Wenjie Zou (ORCID: https://orcid.org/0000-0001-7419-8556)
- Qilin Huang
- Juhua Feng
- Juanhong Li
- Ailin Huang
- Kuan Liu
Institutions
- Sichuan Agricultural University (CN)
Publication Details
- Journal
- Journal of the Chinese Chemical Society
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1002/jccs.70002
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Sichuan Province