A pre-post quasi-experimental study of the impact of TDM-guided aggressive pharmacokinetic/pharmacodynamic target attainment of continuous infusion ceftolozane/tazobactam monotherapy in treating severe <i>Pseudomonas aeruginosa</i> infections: a stra
Our TDM-guided strategy of CI ceftolozane/tazobactam was cost-effective in attaining an aggressive PK/PD target of ceftolozane against susceptible P. aeruginosa strains with lower than standard daily doses without compromising efficacy.
Authors
- Matteo Rinaldi (ORCID: https://orcid.org/0000-0002-3568-5973)
- Tommaso Tonetti (ORCID: https://orcid.org/0000-0001-9676-3595)
- Simone Ambretti (ORCID: https://orcid.org/0000-0002-8358-339X)
- Milo Gatti (ORCID: https://orcid.org/0000-0003-3018-3779)
- Pierluigi Viale (ORCID: https://orcid.org/0000-0003-1264-0008)
- Antonio Daniele Pinna
- Maddalena Giannella (ORCID: https://orcid.org/0000-0001-8273-7601)
- Cecilia Bonazzetti (ORCID: https://orcid.org/0000-0002-5661-1324)
- Federico Pea (ORCID: https://orcid.org/0000-0002-6966-7167)
Institutions
- Azienda USL di Bologna (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1093/jac/dkaf098
- Citations
- 5
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 6.97