Single-cell sequencing reveals PHLDA1-positive smooth muscle cells promote local invasion in head and neck squamous cell carcinoma
PHLDA1-positive smooth muscle cells play a critical role in head and neck squamous cell carcinoma invasion through THBS1. Targeting PHLDA1-positive smooth muscle cells or THBS1 may offer a promising therapeutic approach for head and neck squamous cell carcinoma treatment.
Authors
- Xutao Wen (ORCID: https://orcid.org/0000-0003-1658-5739)
- Bing Guo (ORCID: https://orcid.org/0000-0002-4325-2844)
- Jun Yang (ORCID: https://orcid.org/0000-0002-4901-8530)
- Shun Yu
Institutions
- Jiangnan University (CN)
- Shanghai Stomatological Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1016/j.tranon.2025.102301
- Citations
- 3
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 2.42