GART promotes the proliferation and migration of human non-small cell lung cancer cell lines A549 and H1299 by targeting PAICS-Akt-β-catenin pathway
Our study indicated a tumor-promoting function of GART in LC through the regulation of the PAICS-Akt-β-catenin axis, and it may be used as a therapeutic target for NSCLC.
Authors
- Xuming Ji (ORCID: https://orcid.org/0000-0002-3328-6469)
- Manyu Zhao (ORCID: https://orcid.org/0009-0006-2566-9300)
- Mengying Sun (ORCID: https://orcid.org/0000-0002-8947-0345)
- Qian Xiang (ORCID: https://orcid.org/0000-0002-8245-2611)
- Yongjun Zhang (ORCID: https://orcid.org/0000-0001-9326-1012)
- Zhuo Chen (ORCID: https://orcid.org/0000-0002-6351-8689)
- Aiqin Zhang (ORCID: https://orcid.org/0000-0003-4931-0619)
- Yu-Heng Ding
Institutions
- Zhejiang Chinese Medical University (CN)
- Zhejiang Cancer Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-03-25
- DOI
- https://doi.org/10.3389/fonc.2025.1543463
- Citations
- 1
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.81