Single-cell RNA sequencing reveals the heterogeneity and regulatory modules of cell-specific RNA-binding proteins in patients with systemic lupus erythematosus
Our multi-omics integration identifies JUN and HLA-A as central coordinators of alternative splicing programs in SLE T cells. These molecular hubs, embedded within immune regulatory networks, may drive pathogenic rewiring of T cell responses in SLE.
Authors
- Lili Yang (ORCID: https://orcid.org/0000-0001-5220-3094)
- Wen Cheng (ORCID: https://orcid.org/0000-0003-3975-0389)
- Daan Nie
- Sheng‐Yan Lin
- Yu Chen (ORCID: https://orcid.org/0000-0002-1979-1418)
- Yikai Yu
- Yuxue Chen
- Zhipeng Zeng
Institutions
- Huaihua University (CN)
- Xiaogan First People's Hospital (CN)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1016/j.bbrep.2025.101977
- Citations
- 1
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 1.67
Funders
- National Natural Science Foundation of China
- Huazhong University of Science and Technology
- Tongji Hospital