Angiogenesis Is Associated With Aggressive Biology That Counterbalances With Tumor Immunogenicity in Hepatocellular Carcinoma
Angiogenesis quantified using transcriptome of HCC patients demonstrated that it is associated with aggressive biology but also with tumor immunogenicity and immune response that counterbalance and did not reflect in survival. Given high expression of immune checkpoint molecules, we cannot help but speculate that immunotherapy may be useful for high angiogenesis HCC patients.
Authors
- Takashi Ishikawa (ORCID: https://orcid.org/0000-0003-0247-7729)
- Kaity Tung (ORCID: https://orcid.org/0000-0002-1780-123X)
- Kazuaki Takabe (ORCID: https://orcid.org/0000-0002-6435-4241)
- Raj G. Vaghjiani
- Rongrong Wu (ORCID: https://orcid.org/0009-0000-5512-4383)
Institutions
- Roswell Park Comprehensive Cancer Center (US)
- Fukushima Medical University (JP)
- Tokyo Medical University (JP)
- University at Buffalo, State University of New York (US)
- Niigata University (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- World Journal of Oncology
- Published
- 2025-03-25
- DOI
- https://doi.org/10.14740/wjon2009
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- National Institutes of Health