Single-cell sequencing and spatial transcriptomics reveal the evolution of glucose metabolism in hepatocellular carcinoma and identify G6PD as a potential therapeutic target
Our study provides novel insights into the changes in glucose metabolism in HCC from both temporal and spatial perspectives. We experimentally demonstrated that G6PD regulates proliferation, migration, and invasion in HCC and propose G6PD as a prognostic marker and therapeutic metabolic target for the HCC.
Authors
- Xuebing Yan (ORCID: https://orcid.org/0000-0001-9069-5907)
- Deyang Xi
- Yinshuang Yang
- Chunyang Li (ORCID: https://orcid.org/0000-0002-5798-2274)
- Jiayi Guo (ORCID: https://orcid.org/0009-0005-7004-939X)
- Mengjiao Wang
Institutions
- Xuzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-03-25
- DOI
- https://doi.org/10.3389/fonc.2025.1553722
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.81