Sinomenine Inhibits TOPK To Ameliorate Psoriasiform Dermatitis

Psoriasis is an inflammatory skin disease. Sinomenine is an alkaloid extracted from the rhizome of <i>Sinomenium acutum</i>. Sinomenine plays an important role in inhibiting skin inflammation. However, the mechanism and targets of sinomenine in psoriasis remain unclear. In this study, we found that sinomenine bound and inhibited the TOPK activity <i>in vitro</i>. Moreover, sinomenine inhibited TOPK activation <i>ex</i> and <i>in vivo</i>. Furthermore, sinomenine ameliorated the psoriasiform phenotype <i>in vitro</i> and <i>in vivo</i>. In this study, we determined that TOPK is a potential target of sinomenine to alleviate psoriatic skin inflammation and to provide new processes for clinical treatment.