Reno Protective Role of Propolis Against Chronic Sodiumarsenite Exposure: Apoptotic And Angiogenesis Activity.

Apoptotic activation and regulation of angiogenesis is one of the strategies for prolonged inflammation treatment. The present experiment designed in attempt to investigate the protective role of propolis extract against prolong nephrotoxicity caused by Arsenic exposure via modulating proapoptic marker (caspase3) and angiogenesis vascular endothelial growth factor (VEGF). Thirty female Westar rats were divided into to three groups handled for 60 days as   follows:-1st group : Control , 2nd group: T2 :given 20ppm of AS in drinking water3rd T2Pgroup given  20 ppm of AS  water and gavage  28mg/kg propolis extract. Results of kidney function tests showed significant increase in plasma urea and creatinine  and albuminuria, while eGFR was reduced significantly in 20ppmAs  Immunohistochmestary analysis for caspase3 and VEGF expression showed that propolis extract induced apoptosis via increase caspase3 and reduced the VEGF expression. In conclusion, Propolis extract protective role against arsenic nephrotoxicity mediated by regulation apoptosis  and angiogenesis can be  protected by propolis