Synthesis of C2‐Silylated Indoles and Indolines Enabled by Iridium‐Catalyzed Silylation of Indolines with Hydrosilanes
An efficient iridium‐catalyzed one‐pot protocol is reported for the synthesis of C2‐silylated indoles from indolines and hydrosilanes. Mechanistic investigations suggest that the transformation proceeds through a tandem dehydrogenation/C–H silylation pathway. Furthermore, an example of iridium‐catalyzed direct C2‐selective C( sp 3 )–H silylation of indolines is also disclosed.
Authors
- Hui Sun (ORCID: https://orcid.org/0000-0002-5875-1937)
- Li‐Wen Xu (ORCID: https://orcid.org/0000-0001-5705-0015)
- Xiang‐Ying Tang (ORCID: https://orcid.org/0000-0003-3959-3715)
- Lei Yang (ORCID: https://orcid.org/0000-0001-9172-0879)
- Lei Wang (ORCID: https://orcid.org/0000-0001-6580-7671)
- Wenjie Hu
Institutions
- Hangzhou Normal University (CN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1002/ejoc.202500166
- Citations
- 2
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 1.07