Effect of Exercise on Liver Fat and Lipid Profiles in Non-Alcoholic Fatty Liver Disease: A Hospital-Based Study

Background:The most common cause of liver dysfunction globally is non-alcoholic fatty liver disease (NAFLD), which is becoming more common due to poor lifestyle choices, obesity, and metabolic syndrome.Although exercise and weight loss are advised therapies, the best course of therapy is yet unknown.The purpose of this study is to assess how an aerobic and resistance exercise program affects a patient with non-alcoholic fatty liver disease's body composition and lipid profiles.Methods: A 31-year-old male with NAFLD and no previous exercise history participated in a 12-week exercise program.Blood samples were collected after a 12-hour fast to assess lipid profiles, and a liver ultrasound was performed to evaluate liver fat content.The exercise program combined aerobic and resistance training, progressively increasing in intensity.Results: After the 12-week intervention, the patient showed significant improvements in body composition, including reduced weight (88.9 kg to 75.8 kg), BMI (30.01 to 26.03), body fat (48.1% to 24.2%), and waist-to-hip ratio (0.96 to 0.85).Blood lipid profiles improved with lower total cholesterol (229 mg/dl to 204 mg/dl), LDL (171 mg/dl to 140 mg/dl), and triglycerides (176 mg/dl to 101 mg/dl), while HDL increased (31 mg/dl to 45 mg/dl).Liver fat content decreased from grade II to grade I. Conclusion:The exercise program led to significant improvements in both body composition and lipid profiles, providing evidence that aerobic and resistance exercises can be effective non-pharmacological treatments for NAFLD.Regular exercise may play a critical role in managing and reversing the progression of NAFLD, emphasizing the importance of lifestyle interventions in liver health.