Ultrasound-guided percutaneous radiofrequency ablation combined with anti-PD-1 for the treatment of prostate cancer: an experimental study
Local ablation can improve the therapeutic effect of PD-1 monoclonal antibody. Our preliminary results suggest that ultrasound-guided percutaneous radiofrequency ablation, in combination with anti-PD-1 treatment, produces synergistic effects. These effects may be driven by changes in immune cell populations within the tumor's immunosuppressive microenvironment.
Authors
- Xiguo Cai
- Yingying Zhao (ORCID: https://orcid.org/0000-0001-6308-4043)
- Shaobo Duan (ORCID: https://orcid.org/0000-0003-3150-3666)
- Juan Zhang (ORCID: https://orcid.org/0000-0003-0769-4706)
- Ruiqing Liu (ORCID: https://orcid.org/0000-0002-0282-1967)
- Ru Jang
- Si Chen
- Rui Zhang (ORCID: https://orcid.org/0000-0003-4853-6579)
- Beibei Zhang (ORCID: https://orcid.org/0000-0002-3901-9193)
- Linlin Zhang (ORCID: https://orcid.org/0000-0002-2644-4289)
- Yaqiong Li (ORCID: https://orcid.org/0000-0002-2151-6618)
- Qi Zhou (ORCID: https://orcid.org/0000-0003-2260-0181)
- Lianzhong Zhang (ORCID: https://orcid.org/0000-0003-0886-5589)
- Zesheng Li (ORCID: https://orcid.org/0000-0002-4238-6218)
- Xiaoxiao Li
- Yuzhou Wang
- Xiaoxia Xu
Institutions
- Henan University (CN)
- Zhengzhou University (CN)
- Henan Provincial People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-03-24
- DOI
- https://doi.org/10.3389/fonc.2025.1527763
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05