Single-cell sequencing combined with urinary multi-omics analysis reveals that the non-invasive biomarker PRDX5 regulates bladder cancer progression through ferroptosis signaling
Our study highlights the elevated expression of PRDX5 in BC and its role in promoting tumor progression through regulation of ROS levels and ferroptosis. PRDX5 may serve as a promising target for BC treatment, supporting further exploration of its potential in clinical applications.
Authors
- Tuanjie Che (ORCID: https://orcid.org/0009-0002-6314-6683)
- Shanhui Liu (ORCID: https://orcid.org/0000-0001-9254-5339)
- Shun Wan
- Liyun Ding (ORCID: https://orcid.org/0000-0002-1625-6145)
- Siyu Chen (ORCID: https://orcid.org/0000-0001-5745-5071)
- Yang Li (ORCID: https://orcid.org/0000-0001-9612-2704)
- Chenyang Wang (ORCID: https://orcid.org/0000-0002-8368-7754)
- Jianwei Yang
- Kunpeng Li (ORCID: https://orcid.org/0000-0003-3822-6198)
- Kun Cheng (ORCID: https://orcid.org/0000-0002-1447-1845)
Institutions
- Lanzhou University Second Hospital (CN)
- Annoroad Gene Technology (China) (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1186/s12885-025-13881-y
- Citations
- 3
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 4.56