Longitudinal paired liver biopsies and transcriptome profiling in alcohol-associated hepatitis reveal dynamic changes in cellular senescence
Our results suggest a possible pathogenic role for senescence in AH and indicate cellular senescence as a potential therapeutic target in early ALD to limit AH severity.
Authors
- Alastair M. Kilpatrick (ORCID: https://orcid.org/0000-0002-4795-8799)
- Mark R. Thursz (ORCID: https://orcid.org/0000-0002-8218-192X)
- Stephen R. Atkinson (ORCID: https://orcid.org/0000-0002-6910-7100)
- Victoria L. Gadd (ORCID: https://orcid.org/0000-0003-1819-8660)
- Nikhil Vergis (ORCID: https://orcid.org/0000-0002-4157-6757)
- Rhona Aird (ORCID: https://orcid.org/0000-0002-1014-8063)
- Gavin E. Arteel (ORCID: https://orcid.org/0000-0002-2253-5984)
- Luke D. Tyson (ORCID: https://orcid.org/0000-0003-2745-0282)
- Laura Martínez-Gili (ORCID: https://orcid.org/0000-0001-5271-9672)
- Stuart J. Forbes (ORCID: https://orcid.org/0000-0003-3715-2561)
- Gopal Krishna Dhondalay (ORCID: https://orcid.org/0000-0002-1020-0175)
- Sofía Ferreira-González (ORCID: https://orcid.org/0000-0001-7776-287X)
- Daniel Rodrigo‐Torres (ORCID: https://orcid.org/0000-0001-7840-1523)
- Tak Yung Man (ORCID: https://orcid.org/0000-0002-8452-2417)
Institutions
- University of Pittsburgh (US)
- MRC Centre for Regenerative Medicine (GB)
- Centre for Inflammation Research (GB)
- Imperial College London (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Gut
- Published
- 2025-03-23
- DOI
- https://doi.org/10.1136/gutjnl-2024-334094
- Citations
- 5
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 7.36
Funders
- Chief Scientist Office
- Medical Research Council