Identifying cross-tissue molecular targets of lung function by multi-omics integration analysis from DNA methylation and gene expression of diverse human tissues

This study identified potential cross-tissue molecular targets associated with lung function traits from DNA methylation and gene expression of diverse tissues and explored the probable regulation mechanism of these molecular targets. This provides multi-omics and cross-tissue evidence for the molecular regulation mechanism of lung function and may provide new insight into the influence of crosstalk between organs and tissues on lung function.

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Publication Details

Journal
BMC Genomics
Published
2025-03-24
DOI
https://doi.org/10.1186/s12864-025-11476-2
Primary Topic
Epigenetics and DNA Methylation
Type
article
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article

Identifying cross-tissue molecular targets of lung function by multi-omics integration analysis from DNA methylation and gene expression of diverse human tissues

Senquan Wu, Sichong Peng, Weiliang Mo, Jiayi Fang et al.
BMC Genomics
Epigenetics and DNA Methylation
article

Identifying cross-tissue molecular targets of lung function by multi-omics integration analysis from DNA methylation and gene expression of diverse human tissues

Senquan Wu, Sichong Peng, Weiliang Mo, Jiayi Fang, Guodong Hu
article en

Abstract

This study identified potential cross-tissue molecular targets associated with lung function traits from DNA methylation and gene expression of diverse tissues and explored the probable regulation mechanism of these molecular targets. This provides multi-omics and cross-tissue evidence for the molecular regulation mechanism of lung function and may provide new insight into the influence of crosstalk between organs and tissues on lung function.

BMC GenomicsVol. 26(1)
Dongguan People’s Hospital (CN), Southern Medical University (CN)
Openalex Percentile: Top 95%
Epigenetics and DNA Methylation
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