Mutations in ace2 gene modulate cytokine levels and alter immune responses in Mycobacterium tuberculosis and SARS-CoV-2 co-infection: a Cameroonian cohort

These biomarkers may reflect the complex interplay between the two pathogens and their impact on host immune responses and disease progression. This study highlights the critical role of genetic and immunological factors in shaping altered immune responses during co-infections involving Mtb and SARS-CoV-2. By elucidating these factors, the findings provide a foundation for a deeper understanding of host-pathogen interactions and their implications for disease progression and outcomes. Furthermore, this research has the potential to drive advancements in diagnostic approaches enabling more accurate detection and monitoring of co-infections.

Authors

Institutions

Publication Details

Journal
Frontiers in Immunology
Published
2025-03-24
DOI
https://doi.org/10.3389/fimmu.2025.1533213
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Mutations in ace2 gene modulate cytokine levels and alter immune responses in Mycobacterium tuberculosis and SARS-CoV-2 co-infection: a Cameroonian cohort

Séverin Donald Kamdem, Ranjan Kumar Nanda, John Amuasi, Arnaud Tepa et al.
Frontiers in Immunology
SARS-CoV-2 and COVID-19 Research
article

Mutations in ace2 gene modulate cytokine levels and alter immune responses in Mycobacterium tuberculosis and SARS-CoV-2 co-infection: a Cameroonian cohort

Séverin Donald Kamdem, Ranjan Kumar Nanda, John Amuasi, Arnaud Tepa, Jean Paul Assam Assam, Anthony Afum-Adjei Awuah, Eric Berenger Tchoupe, Palmer Masumbe Netongo, Fuh Roger Neba, Nikhil Bhalla, Mary Ngongang Kameni
article en

Abstract

These biomarkers may reflect the complex interplay between the two pathogens and their impact on host immune responses and disease progression. This study highlights the critical role of genetic and immunological factors in shaping altered immune responses during co-infections involving Mtb and SARS-CoV-2. By elucidating these factors, the findings provide a foundation for a deeper understanding of host-pathogen interactions and their implications for disease progression and outcomes. Furthermore, this research has the potential to drive advancements in diagnostic approaches enabling more accurate detection and monitoring of co-infections.

Frontiers in ImmunologyVol. 16
Université de Yaoundé I (CM), University of Utah (US), Navajo Technical University (US), Kwame Nkrumah University of Science and Technology (GH), Kumasi Centre for Collaborative Research in Tropical Medicine (GH), International Centre for Genetic Engineering and Biotechnology (IN), Bernhard Nocht Institute for Tropical Medicine (DE)
Wellcome Trust, European and Developing Countries Clinical Trials Partnership
Good health and well-being
Openalex Percentile: Top 92%
SARS-CoV-2 and COVID-19 Research
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.