A clinical case of leuckemoid reaction in newborn with congenital pneumonia

Being a rather rare, but at the same time extremely important finding in the general blood test, the leukemoid reaction (LR) is a short-term sharp increase in the level of leukocytes above 30—50 x 10 9 /l with a shift of the leukocyte formula to the left. The development of this condition may be due to a number of factors, but in pediatric practice, LR is primarily associated with prematurity, the course of the infectious process (most often pneumonia), extremely low body weight, taking certain medications both by the mother during pregnancy and by the child, chromosomal abnormalities and others. Of particular importance to the study of LR is the fact that similar changes in peripheral blood are observed in a number of other diseases, including the course of malignant processes — leukemia, which requires a competent approach to differential diagnosis, the involvement of various specialists and makes LR an exception diagnosis.

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Publication Details

Journal
CHILDREN INFECTIONS
Published
2025-03-24
DOI
https://doi.org/10.22627/2072-8107-2025-24-1-56-62
Primary Topic
Neonatal Respiratory Health Research
Type
article
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article

A clinical case of leuckemoid reaction in newborn with congenital pneumonia

П.В. Шумилов, H. A. Sarkisyan, Л. М. Макарова, М. М. Нассер et al.
CHILDREN INFECTIONS
Neonatal Respiratory Health Research
article

A clinical case of leuckemoid reaction in newborn with congenital pneumonia

П.В. Шумилов, H. A. Sarkisyan, Л. М. Макарова, М. М. Нассер, Yu. V. Zhirkova, O. V. Tsilinskaya, A. P. Khokhlova, T. S. Kurina, E. E. Melkumyan, L. A. Vanyan
article en

Abstract

Being a rather rare, but at the same time extremely important finding in the general blood test, the leukemoid reaction (LR) is a short-term sharp increase in the level of leukocytes above 30—50 x 10 9 /l with a shift of the leukocyte formula to the left. The development of this condition may be due to a number of factors, but in pediatric practice, LR is primarily associated with prematurity, the course of the infectious process (most often pneumonia), extremely low body weight, taking certain medications both by the mother during pregnancy and by the child, chromosomal abnormalities and others. Of particular importance to the study of LR is the fact that similar changes in peripheral blood are observed in a number of other diseases, including the course of malignant processes — leukemia, which requires a competent approach to differential diagnosis, the involvement of various specialists and makes LR an exception diagnosis.

CHILDREN INFECTIONSVol. 24(1)
Pirogov Russian National Research Medical University (RU), Ministry of Health of the Russian Federation (RU), City Clinical Hospital (RU)
Openalex Percentile: Top 92%
Neonatal Respiratory Health Research
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A clinical case of leuckemoid reaction in newborn with congenital pneumonia — П.В. Шумилов, H. A. Sarkisyan, et al. · CHILDREN INFECTIONS (2025) | TGRS Research Map | TGRS