Plasma extracellular cold inducible RNA-binding protein levels are elevated for 1 month post-colectomy which may promote metastases
Elevated plasma eCIRP levels persist for a month post MICR for CRC (change from baseline, 77%-184%); highest values seen on POD1. The initial surge may be due to the acute inflammatory response while later elevations may be related to wound healing and remodeling. The higher levels noted in the HAL's group (with greater IL and more rectal cases) suggest the extent of surgical trauma impacts eCIRP levels. Further investigations are needed.
Authors
- Poppy Addison (ORCID: https://orcid.org/0000-0002-7636-106X)
- Vesna Cekic (ORCID: https://orcid.org/0000-0002-8130-6540)
- W. Richard
- H. M. C. Shantha Kumara
- Hansani N. Angammana
- Neil Mitra (ORCID: https://orcid.org/0000-0003-2731-7457)
- Yanni Hedjar (ORCID: https://orcid.org/0000-0002-1556-2837)
- Yan Xiaohong (ORCID: https://orcid.org/0009-0002-6113-6326)
- Anuj Sharma (ORCID: https://orcid.org/0000-0002-8240-0539)
- Yi-Ru Chen
Institutions
- Northwell Health (US)
- Hofstra University (US)
- Columbia University Irving Medical Center (US)
- Lenox Hill Hospital (US)
- Staten Island University Hospital (US)
- Brookdale University Hospital and Medical Center (US)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
- North Shore Diabetes and Endocrine Associates (US)
Publication Details
- Journal
- World Journal of Gastrointestinal Oncology
- Published
- 2025-03-24
- DOI
- https://doi.org/10.4251/wjgo.v17.i4.100678
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.00