Antiviral Activity of Halogenated Compounds Derived from L-Tyrosine Against SARS-CoV-2
The most promising compounds were TODC-3M, TODI-2M, and YODC-3M, which presented low in vitro and in silico toxicity, antiviral potential through different strategies, and favorable affinities for viral targets. Therefore, they are candidates for in vivo studies.
Authors
- María I. Zapata-Cardona (ORCID: https://orcid.org/0000-0003-2714-9190)
- Manuel Pastrana Restrepo (ORCID: https://orcid.org/0000-0003-4305-241X)
- Elkin Galeano (ORCID: https://orcid.org/0000-0002-8801-6239)
- Diego Guerra (ORCID: https://orcid.org/0000-0002-1332-9169)
- Wildeman Zapata (ORCID: https://orcid.org/0000-0002-7351-8738)
- Jaime Andrés Pereañez (ORCID: https://orcid.org/0000-0001-9612-2827)
- Laura Milena Monsalve-Escudero (ORCID: https://orcid.org/0000-0002-6493-7455)
- Paula A. Velásquez-Bedoya
Institutions
- Consejo Superior de Investigaciones Científicas (ES)
- Universidad de Antioquia (CO)
- Universidad Cooperativa de Colombia (CO)
- Instituto de Parasitología y Biomedicina "López - Neyra" (ES)
Publication Details
- Journal
- Molecules
- Published
- 2025-03-22
- DOI
- https://doi.org/10.3390/molecules30071419
- Citations
- 1
- Primary Topic
- Computational Drug Discovery Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.50