Tetramethylpyrazine induces reactive oxygen species-based mitochondria-mediated apoptosis in colon cancer cells
Our study demonstrates that TMP induces the apoptosis of colon cancer cells and increases the generation of intracellular ROS. TMP triggers mitochondria-mediated apoptosis in a caspase-dependent manner. The accumulation of intracellular ROS is involved in TMP-induced apoptosis. Our findings suggest that TMP may be a potential therapeutic drug for the treatment of colon cancer.
Authors
- Tian-Hua Gao
- Qing-Qiang He
- Wei Ren (ORCID: https://orcid.org/0000-0001-7571-5623)
- Hua Li (ORCID: https://orcid.org/0000-0003-2153-2500)
- Liyan Huang (ORCID: https://orcid.org/0000-0003-3966-6195)
- Yan-Xu Hou
Institutions
- Hebei Medical University (CN)
- Xingtai People's Hospital (CN)
Publication Details
- Journal
- World Journal of Gastrointestinal Oncology
- Published
- 2025-03-24
- DOI
- https://doi.org/10.4251/wjgo.v17.i4.104922
- Citations
- 1
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 2.38