Nutritional support of oocyteogenesis, ovulatory menstrual cycles with folate cycle vitamins (vitamins B1, B6, B12, active form B9) and vitamin B8 vitamers (Myo- and D-chiroinositol in a ratio of 40:1) during pre-conception preparation

The roles of folates (vitamin B9) in the formation of healthy oocytes (which is important for preventing malformations) are well known. Other B vitamins are also necessary for the physiological effects of folates to be realized: vitamins B1, B6, B12, and B8 (inositols). Myoinositol (MI) and D-chiroinositol (DCI) are the two most studied inositols necessary for supporting oocytes, restoring ovulatory cycles, and preventing folate-resistant malformations. DCI and MI metabolism is impaired against the background of insulin resistance, including in patients with obesity and polycystic ovary syndrome (PCOS). Conversely, supplementing patients with MI and DCI in a physiological ratio of 40:1 helps eliminate insulin resistance, hyperandrogenism, and anovulation, which prevent the formation of healthy oocytes and, consequently, conception.