Exploratory Study to Evaluate the Impact of Interim PET/CT Assessment in First-Line Follicular Lymphoma
<b>Background/Objectives</b>: This study aimed to determine whether interim PET/CT (iPET) scans could identify follicular lymphoma (FL) patients at high risk of relapse following first-line therapy. <b>Methods</b>: A total of 117 FL patients who underwent iPET scans were included, with responses interpreted using the Deauville score (DS). Progression-free survival (PFS) was evaluated over a median follow-up of 34 months. <b>Results</b>: Overall, 34% of patients were classified as iPET (+), with significantly worse estimated 5-year PFS compared to iPET (-) patients (34% vs. 76%, hazard ratio 4.3, <i>p</i> < 0.001). Multivariate analysis confirmed iPET (+) as an independent predictor of PFS. <b>Conclusions</b>: Interim PET results are significant predictors of PFS in FL first-line therapy and could inform response-adapted treatment strategies.
Authors
- Carlos Grande (ORCID: https://orcid.org/0000-0001-7227-1975)
- Antonia Rodríguez-Izquierdo (ORCID: https://orcid.org/0000-0001-6330-7729)
- Ana Carla Oliveira (ORCID: https://orcid.org/0000-0002-1543-7243)
- Ana Jiménez Ubieto (ORCID: https://orcid.org/0000-0003-0892-8682)
- Santiago Barrio (ORCID: https://orcid.org/0000-0003-0793-3535)
- Joaquín Martínez‐López (ORCID: https://orcid.org/0000-0001-7908-0063)
- Alejandro Martín-Muñoz (ORCID: https://orcid.org/0000-0002-5180-5760)
- Irene Zamanillo
- María Poza (ORCID: https://orcid.org/0000-0001-6811-0933)
- Rodrigo Íñiguez (ORCID: https://orcid.org/0000-0002-2804-5038)
- Pilar Sarandeses (ORCID: https://orcid.org/0000-0002-1415-345X)
- Enrique Revilla (ORCID: https://orcid.org/0000-0001-5394-5401)
- Gloria Figaredo (ORCID: https://orcid.org/0000-0002-4031-9601)
- Rosa María Ayala (ORCID: https://orcid.org/0000-0002-2699-8353)
- Tycho Baumann (ORCID: https://orcid.org/0000-0003-4421-0088)
- María Calbacho (ORCID: https://orcid.org/0000-0001-8106-4863)
- Patricia López‐Pereira (ORCID: https://orcid.org/0009-0003-8279-6259)
- Montserrat Cortés
Institutions
- Hospital General Universitario Gregorio Marañón (ES)
- Research Institute Hospital 12 de Octubre (ES)
- Hospital Universitario 12 De Octubre (ES)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
- Clinica Universidad de Navarra (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
Publication Details
- Journal
- Cancers
- Published
- 2025-03-21
- DOI
- https://doi.org/10.3390/cancers17071065
- Citations
- 3
- Primary Topic
- Lymphoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- European Commission
- CRIS Cancer Foundation
- Instituto de Salud Carlos III