Molecular Alterations in TP53, WNT, PI3K, TGF-Beta, and RTK/RAS Pathways in Gastric Cancer Among Ethnically Heterogeneous Cohorts
This study provides one of the first ethnicity-focused analyses of TP53, WNT, PI3K, TGF-Beta, and RTK/RAS pathway alterations in GC, revealing significant racial/ethnic differences in pathway dysregulation. The findings suggest that TP53 and WNT alterations may play a critical role in GC among H/L patients, while PI3K and TGF-Beta alterations may have greater prognostic significance in NHW patients. These insights emphasize the need for precision medicine approaches that account for genetic heterogeneity and ethnicity-specific pathway alterations to improve cancer care and outcomes for underrepresented populations.
Authors
- Francisco Carranza (ORCID: https://orcid.org/0000-0003-1789-4197)
- Enrique Velazquez‐Villarreal (ORCID: https://orcid.org/0000-0002-3603-6414)
- Cecilia Monge (ORCID: https://orcid.org/0000-0002-5558-2744)
- Brigette Waldrup (ORCID: https://orcid.org/0009-0009-5991-9779)
Institutions
- City of Hope (US)
- National Cancer Institute (US)
- Center for Cancer Research (US)
- Beckman Research Institute
Publication Details
- Journal
- Cancers
- Published
- 2025-03-23
- DOI
- https://doi.org/10.3390/cancers17071075
- Citations
- 10
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 9.36
Funders
- Beckman Research Institute, City of Hope
- Comprehensive Cancer Center, City of Hope
- National Institutes of Health
- National Cancer Institute
- Moonshot Research and Development Program
- Cancer Moonshot