Four Faces of Infective Endocarditis: Where Thinking Outside the Box Was Crucial

<b>Background/Objectives:</b> Infective Endocarditis (IE) presents both a challenging diagnostic and treatment task. <b>Methods:</b> The incidence of IE has grown with the advancement in treatment technologies offered to patients, including intra-cardiac electrical device insertion and a variety of transcutaneous structural interventions. <b>Results:</b> Guidelines recommend the involvement of a multi-disciplinary approach to prompt diagnosis and decisions regarding treatment. <b>Conclusions:</b> We present the management conundrums of four complex cases of IE and highlight the importance of the Extended Endocarditis Team.