Mfn2 regulates calcium homeostasis and suppresses PASMCs proliferation via interaction with IP3R3 to mitigate pulmonary arterial hypertension
Mfn2 mediates mitochondrial Ca<sup>2+</sup> transport via IP3R3, suppressing PASMCs proliferation and pulmonary vascular remodeling, underscoring Mfn2's potential in regulating metabolic processes and vascular remodeling in PAH. These findings provide new insights for developing PAH-targeted therapeutics and establish a theoretical basis for traditional Chinese medicine in PAH prevention and treatment.
Authors
- Jing Yu (ORCID: https://orcid.org/0000-0001-7752-9971)
- Yuhu Chen (ORCID: https://orcid.org/0000-0002-0228-3126)
- Yun Wu (ORCID: https://orcid.org/0000-0002-2692-9067)
- Jingfei Guo (ORCID: https://orcid.org/0000-0002-6771-9832)
- Minfang Zhang
- R. Wang (ORCID: https://orcid.org/0000-0002-0988-213X)
- Zhiqiang Li (ORCID: https://orcid.org/0009-0007-8786-5945)
- Xiaomei Li (ORCID: https://orcid.org/0000-0002-4118-2715)
- Jie Wang (ORCID: https://orcid.org/0000-0001-7905-034X)
- Fen Liu
- Dongmei Jiang (ORCID: https://orcid.org/0000-0002-6238-8499)
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1186/s12967-025-06384-8
- Citations
- 14
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 21.26
Funders
- National Natural Science Foundation of China