<i>Map3k3 </i> <sup>I441M</sup> Knock-In Mouse Model of Cerebral Cavernous Malformations
<i>Map3k3</i><sup>I441M</sup> heterozygous is sufficient to induce lesions in juvenile mice, while the additional activation of PI3K signaling is required for the effective formation of CCMs at the adult stage. The <i>Map3k3</i><sup>I441M</sup> murine model provides a preclinical model for further mechanistic and therapeutic studies of CCMs.
Authors
- Qiheng He (ORCID: https://orcid.org/0000-0001-6715-298X)
- Qiuxia Zhou (ORCID: https://orcid.org/0000-0003-3578-8056)
- Yingxi Yang (ORCID: https://orcid.org/0000-0001-5153-2769)
- Yong Cao (ORCID: https://orcid.org/0000-0002-8289-1120)
- Ran Huo (ORCID: https://orcid.org/0000-0003-4708-3133)
- Yuming Jiao (ORCID: https://orcid.org/0000-0001-8351-4602)
- Yingfan Sun
- Shaozhi Zhao (ORCID: https://orcid.org/0000-0001-7527-5226)
- Jie Wang (ORCID: https://orcid.org/0000-0001-8499-5866)
- Jiguang Wang (ORCID: https://orcid.org/0000-0002-6923-4097)
- Hongyuan Xu (ORCID: https://orcid.org/0000-0001-9294-8349)
- Jinyi Tang
- Qifeng Yu
Institutions
- Hong Kong University of Science and Technology (HK)
- Beijing Tian Tan Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Beijing Institute of Neurosurgery (CN)
- Institut de Biologia Evolutiva (ES)
- University of Hong Kong (HK)
Publication Details
- Journal
- Stroke
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1161/strokeaha.124.049935
- Citations
- 7
- Primary Topic
- Vascular Malformations Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 9.72