Ag(I)‐Catalyzed Intramolecular Cascade Cyclization to Construct [6–5–7–6] Heterotetracyclic (−N and −O) Indole Fused Scaffolds

Abstract Herein, we report a silver‐catalyzed intramolecular cascade reaction of 2‐alkynylaniline tethered heteroenone systems to achieve the synthesis of [6–5–7–6] heterotetracyclic indole fused benzoxepino‐ and benzoazepino scaffolds. The reaction proceeded through a silver(I)‐initiation cascade intramolecular 5‐endo‐dig cyclization followed by 7‐exo‐trig cyclization to enable the structurally diverse [6–5–7–6] heterotetracyclic adducts in modest to good yields.