A novel rat model of lumbar disc herniation induced by puncture: accurate positioning and controllable degree of herniation
We have successfully constructed rat models of different types of intervertebral disc herniation, including disc degeneration, bulging, central herniation, and lateral herniation, using the method of puncture of intervertebral discs. This animal model is consistent with the characteristics of LDH in terms of behavior, imaging, and histopathology.
Authors
- Jiangling Zhou (ORCID: https://orcid.org/0000-0001-7466-5273)
- Qiandong Yang
- Ming Yang (ORCID: https://orcid.org/0000-0002-2954-7435)
- Bo Yu (ORCID: https://orcid.org/0000-0001-9765-1341)
- Juan Cai (ORCID: https://orcid.org/0009-0001-6815-5629)
- Tianyong Hou (ORCID: https://orcid.org/0000-0001-6966-1198)
Institutions
- Army Medical University (CN)
- Southwest Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-03-25
- DOI
- https://doi.org/10.1186/s13018-025-05710-6
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00