Warfarin Pharmacogenomics: Designing Electrochemical DNA-Based Sensors to Detect CYP2C9*2 Gene Variation
The developed electrochemical DNA-based sensor was able to discriminate two synthetic SNP target sequences (Target-A and Target-G) and detect, with specificity, the three patients' genotypes (G/G, G/A, and A/A). This tool is therefore a promising, sensitive, and cost-effective analytical way to determine and discriminate an individual's genotype and predict the appropriate warfarin dose.
Authors
- Marlene Santos (ORCID: https://orcid.org/0000-0001-5020-5942)
- Stephanie L. Morais (ORCID: https://orcid.org/0000-0002-0341-4511)
- Eduarda Pereira (ORCID: https://orcid.org/0000-0003-2721-7069)
- Júlia M. C. S. Magalhães (ORCID: https://orcid.org/0000-0001-8436-0692)
- M. Fátima Barroso (ORCID: https://orcid.org/0000-0001-9011-5992)
- Hygor Ferreira-Fernandes (ORCID: https://orcid.org/0000-0001-5689-5876)
- Tiago Barbosa (ORCID: https://orcid.org/0009-0003-7654-3095)
- Valentina F. Domingues (ORCID: https://orcid.org/0000-0003-3472-849X)
- Giovanny R. Pinto (ORCID: https://orcid.org/0000-0001-9110-1840)
Institutions
- Universidade do Porto (PT)
- IPO Porto (PT)
- Instituto Federal do Piauí (BR)
- Rede de Química e Tecnologia (PT)
- Polytechnic Institute of Porto (PT)
Publication Details
- Journal
- Genes
- Published
- 2025-03-24
- DOI
- https://doi.org/10.3390/genes16040372
- Citations
- 1
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.56