Clinical characterization of necrotizing enterocolitis in neonates with or without congenital heart disease: a case–control study
Children with CHD-NEC and nCHD-NEC have significantly different clinical characteristics. CHD-NEC is mainly observed in full-term infants with appropriate weight for gestational age, and perioperative intestinal ischemia may be the main pathophysiology. Conversely, nCHD-NEC is mainly noted in preterm infants, possibly related to immature intestinal development and infection. Large prospective clinical research is warranted to explore the pathogenesis, pathophysiology, indicator monitoring, and treatment plan for children with NEC.
Authors
- Zhuoming Xu (ORCID: https://orcid.org/0000-0001-5695-8662)
- Kaiyishaer Balati
- Xiaolei Gong (ORCID: https://orcid.org/0009-0000-7352-3839)
- Limin Zhu (ORCID: https://orcid.org/0000-0002-5224-9962)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Children's Medical Center (CN)
- Xian Yang Central Hospital (CN)
Publication Details
- Journal
- The Italian Journal of Pediatrics/Italian journal of pediatrics
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1186/s13052-025-01928-6
- Citations
- 1
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 1.12