Ferrostatin-1 inhibits tracheal basal cell ferroptosis to facilitate the rapid epithelization of 3D-printed tissue-engineered tracheas
Ferrostatin-1 effectively inhibits ferroptosis in tracheal basal cells, promoting their viability and proliferation. This results in faster epithelialization of tissue-engineered tracheas, offering a promising strategy for improving tracheal reconstruction outcomes and reducing complications such as infection and granulation tissue formation. Future studies are needed to further investigate the molecular mechanisms underlying ferroptosis in TBCs and its potential clinical applications.
Authors
- Guangyong Zeng (ORCID: https://orcid.org/0000-0001-6837-2618)
- He Cai (ORCID: https://orcid.org/0000-0002-6543-3478)
- Kai Luo (ORCID: https://orcid.org/0000-0002-1345-8243)
- Bozhong Shi (ORCID: https://orcid.org/0000-0003-3794-6601)
- Cong Li (ORCID: https://orcid.org/0000-0001-7731-8031)
- Bo Chen (ORCID: https://orcid.org/0000-0002-7974-9051)
- Jinghao Zheng (ORCID: https://orcid.org/0000-0001-7459-6730)
- Xiaoyang Zhang (ORCID: https://orcid.org/0000-0003-1420-9385)
- Xiaomin He (ORCID: https://orcid.org/0000-0002-6079-1014)
Institutions
- Shanghai Jiao Tong University (CN)
- Shanghai Children's Medical Center (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1186/s13287-025-04263-z
- Citations
- 1
- Primary Topic
- Tracheal and airway disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- Shanghai Hospital Development Center