Loss of FXR or Bile Acid-dependent Inhibition Accelerate Carcinogenesis of Gastroesophageal Adenocarcinoma
GEAC carcinogenesis appears to be partially driven via loss or inhibition of FXR on progenitor cells at the gastroesophageal junction. Considering that the resulting aggravation in the phenotype could be reversed with OCA treatment, we suggest that FXR agonists have great potential as a preventive strategy against GEAC progression.
Authors
- Veronika Somoza (ORCID: https://orcid.org/0000-0003-2456-9245)
- Akanksha Anand (ORCID: https://orcid.org/0009-0000-7786-3179)
- Martin Borgmann (ORCID: https://orcid.org/0000-0002-8195-2796)
- Yiwei Sun (ORCID: https://orcid.org/0000-0002-5974-6232)
- Mohammed Khiat
- Chen Meng (ORCID: https://orcid.org/0000-0002-5968-6719)
- Katrin Böttcher (ORCID: https://orcid.org/0000-0002-4154-8270)
- Harris H. Wang (ORCID: https://orcid.org/0000-0003-2164-4318)
- Dirk Haller (ORCID: https://orcid.org/0000-0002-6977-4085)
- Michael Quante (ORCID: https://orcid.org/0000-0002-8497-582X)
- Linus Schömig
- Andreas Dunkel (ORCID: https://orcid.org/0000-0002-4445-6144)
- Robert Thimme (ORCID: https://orcid.org/0000-0003-1417-4135)
- Deepa T. Patil (ORCID: https://orcid.org/0000-0001-7837-1299)
- Elke Burgermeister (ORCID: https://orcid.org/0000-0002-4969-5697)
- Andrea Proaño-Vasco (ORCID: https://orcid.org/0009-0001-5225-5588)
- Sinah Reiter
- Theresa Baumeister (ORCID: https://orcid.org/0000-0002-3233-1205)
- Julian A. Abrams (ORCID: https://orcid.org/0000-0002-6021-9376)
- Julia Strangmann
- Amira Metwaly (ORCID: https://orcid.org/0000-0001-5740-0230)
- Karin Kleigrewe (ORCID: https://orcid.org/0000-0002-7718-0252)
- Timothy C. Wang (ORCID: https://orcid.org/0000-0001-5730-3019)
- Yiming Huang (ORCID: https://orcid.org/0000-0001-5967-557X)
- Alexander Kuznetsov (ORCID: https://orcid.org/0000-0002-4740-0277)
- Roland M. Schmid (ORCID: https://orcid.org/0009-0000-8976-3300)
Institutions
- University of Freiburg (DE)
- Heidelberg University (DE)
- Columbia University Irving Medical Center (US)
- University Medical Center Freiburg (DE)
- University Hospital Heidelberg (DE)
- Klinik und Poliklinik für Urologie (DE)
- Leibniz-Institute for Food Systems Biology at the Technical University of Munich (DE)
- University Medical Centre Mannheim (DE)
- Case Western Reserve University (US)
- Technical University of Munich (DE)
- Heidelberg University (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101505
- Citations
- 7
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 10.63
Funders
- Wilhelm Sander-Stiftung
- Deutsche Forschungsgemeinschaft
- National Institutes of Health