A GWAS of angiotensin-converting enzyme inhibitor-induced angioedema in a South African population
Our results highlight the importance of African populations for detection of novel variants in replication studies. Further increased sampling across the continent and matched functional work are needed to confirm the importance of genetic variation in understanding the biology of AE-ACEI.
Authors
- Lisa K. Micklesfield (ORCID: https://orcid.org/0000-0002-4994-0779)
- Robert Freercks (ORCID: https://orcid.org/0000-0002-7939-1352)
- Jonny Peter (ORCID: https://orcid.org/0000-0002-2658-0723)
- Ananyo Choudhury (ORCID: https://orcid.org/0000-0001-8225-9531)
- Angelica Panieri
- Cascia Day (ORCID: https://orcid.org/0000-0002-8090-3861)
- Jacquiline W Mugo (ORCID: https://orcid.org/0000-0003-0008-4358)
- Michèle Ramsay (ORCID: https://orcid.org/0000-0002-4156-4801)
- Sarah Pedretti (ORCID: https://orcid.org/0000-0003-4005-8453)
- Maria Deetlefs
- Sian Geraty
- Melissa Ribeiro
- Adelein Engelbrecht
- Christian Cotchobos
Institutions
- South African Medical Research Council (ZA)
- University of Cape Town (ZA)
- University of the Witwatersrand (ZA)
- University of Johannesburg (ZA)
- City of Cape Town (ZA)
- Anova Health Institute (ZA)
- Nelson Mandela University (ZA)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology Global
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1016/j.jacig.2025.100464
- Citations
- 1
- Primary Topic
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Type
- article
- Field-Weighted Citation Impact
- 1.63