Mutation of the LRG1 Rho-GAP gene is responsible for the hyper branching C-variant phenotype in the quorn mycoprotein fungus Fusarium venenatum A3/5
This study identified mutations in the LRG1 ortholog jg4843 as the genetic cause of C-variant morphology in commercial fermentation F. venenatum isolates. Understanding this genetic basis paves the way for developing strategies to prevent C-variants arising, potentially leading to more efficient and sustainable production of Quorn mycoprotein.
Authors
- R. Jordan Price (ORCID: https://orcid.org/0000-0003-0930-3246)
- Helen J. Bates (ORCID: https://orcid.org/0000-0002-7978-9213)
- Fiona Wilson (ORCID: https://orcid.org/0000-0002-2073-7400)
- Ivey A. Geoghegan (ORCID: https://orcid.org/0000-0002-4921-7177)
- Richard J. Harrison (ORCID: https://orcid.org/0000-0002-3307-3519)
- John Connell
Institutions
- East Malling Research (United Kingdom) (GB)
- National Institute of Agricultural Botany (GB)
- Cambridge Research Biochemicals (United Kingdom) (GB)
- University of Birmingham (GB)
- Wageningen University & Research (NL)
Publication Details
- Journal
- Fungal Biology and Biotechnology
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1186/s40694-025-00195-8
- Citations
- 2
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- James Hutton Institute
- Directorate for Biological Sciences
- Biotechnology and Biological Sciences Research Council