Prevalence of Serotonergic Drug Use in Patients Exposed to Perioperative Methylene Blue: A Cross-Sectional Study

The prevalence of serotonergic agent use in patients administered methylene blue is relatively high exceeding 10%, with the highest prevalence observed in those on SSRIs, followed by SNRIs and TCAs. This underscores the importance of a thorough preoperative evaluation by an anesthesiologist to minimize the risk of intraoperative complications such as serotonin syndrome.

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Publication Details

Journal
Cureus
Published
2025-03-24
DOI
https://doi.org/10.7759/cureus.81090
Primary Topic
Anesthesia and Sedative Agents
Type
article
Field-Weighted Citation Impact
0.00
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article

Prevalence of Serotonergic Drug Use in Patients Exposed to Perioperative Methylene Blue: A Cross-Sectional Study

Miriam B Michael, Trinity Gibbs, Samrawit Zinabu, Elijah McMillan et al.
Cureus
Anesthesia and Sedative Agents
article

Prevalence of Serotonergic Drug Use in Patients Exposed to Perioperative Methylene Blue: A Cross-Sectional Study

Miriam B Michael, Trinity Gibbs, Samrawit Zinabu, Elijah McMillan, Noah Wheaton, Nurupa Ramkissoon, Da’Jhai Monroe, Shawn Meepagala, Kamdili Ogbutor
article en

Abstract

The prevalence of serotonergic agent use in patients administered methylene blue is relatively high exceeding 10%, with the highest prevalence observed in those on SSRIs, followed by SNRIs and TCAs. This underscores the importance of a thorough preoperative evaluation by an anesthesiologist to minimize the risk of intraoperative complications such as serotonin syndrome.

CureusVol. 17(3)
University of Maryland, Baltimore (US), Howard University (US), Howard University Hospital (US)
Good health and well-being
Openalex Percentile: Top 89%
Anesthesia and Sedative Agents
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