Inosine monophosphate overcomes the coexisting resistance of mcr-1 and blaNDM-1 in Escherichia coli
Our findings suggest that IMP could be a promising candidate for combating mcr-1 and bla<sub>NDM-1</sub>-mediated resistance and provide a novel approach for discovering antimicrobial agents against colistin- and carbapenem-resistant bacteria.
Authors
- Xixi Jia (ORCID: https://orcid.org/0000-0003-4780-2900)
- Jingjing Du (ORCID: https://orcid.org/0000-0002-8563-7697)
- Xi Xia (ORCID: https://orcid.org/0000-0002-9630-7909)
- Saiwa Liu
- Yu Ga
- Liang Zhao (ORCID: https://orcid.org/0000-0002-4240-9264)
- Zhinan Wang
- Lirui Ge
- Xiaowei Li (ORCID: https://orcid.org/0000-0002-4850-1301)
- Kexin Cui
- Jian Xu (ORCID: https://orcid.org/0000-0003-2032-251X)
Institutions
- China Agricultural University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1016/j.jare.2025.03.043
- Citations
- 3
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- National Key Research and Development Program of China
- National Key Research and Development Program of China Stem Cell and Translational Research