Dysregulation of the tumor suppressor Menin and its target Bach2 in HTLV-1 infection
HTLV-1 infection alters the regulation of the Menin-Bach2 pathway, which controls cell proliferation. The Menin-MLL interaction inhibitor loses its effectiveness in suppressing cell proliferation when Menin loses control over Bach2 expression. Dysregulation of the Menin-Bach2 pathway may contribute to HTLV-1-associated disease pathogenesis.
Authors
- Hiroe Sejima
- Tadasuke Naito (ORCID: https://orcid.org/0009-0008-5385-6140)
- Mineki Saito (ORCID: https://orcid.org/0000-0001-8208-5586)
- Takuya Fukushima (ORCID: https://orcid.org/0000-0001-9422-2875)
Institutions
- Kawasaki Medical School (JP)
- University of the Ryukyus (JP)
Publication Details
- Journal
- Retrovirology
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1186/s12977-025-00660-7
- Citations
- 1
- Primary Topic
- T-cell and Retrovirus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Japan Society for the Promotion of Science