Dysregulation of bile acid signal transduction causes neurological dysfunction in cirrhosis rats
This study demonstrated that the total bile acid content in the serum and cerebral cortex of TAA-induced liver cirrhosis rats was elevated. Furthermore, total bile acids exacerbate the progression of HE in rats. This effect may be attributed to bile acids' involvement in the development of neurological dysfunction by mediating TGR5 expression and regulating neuroinflammation.
Authors
- Guohui Bai (ORCID: https://orcid.org/0000-0002-8095-0633)
- Long Gao
- Li Cha
- Yuxing Feng
- Jinhui Li (ORCID: https://orcid.org/0000-0001-5842-3178)
- Jinyu Li (ORCID: https://orcid.org/0000-0001-6799-0182)
- Duiping Feng (ORCID: https://orcid.org/0000-0003-4516-3797)
- Chao Ren
- Xin Xiong (ORCID: https://orcid.org/0009-0001-6650-8419)
- S. Huang
Institutions
- Shanxi Medical University (CN)
- First Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- World Journal of Hepatology
- Published
- 2025-03-25
- DOI
- https://doi.org/10.4254/wjh.v17.i3.101340
- Citations
- 4
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 5.29