Hepatocellular Carcinoma in a 55-Year-Old with Chronic Hepatitis B: A Case Report on Diagnosis and Management

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, particularly in regions with a high prevalence of chronic hepatitis B virus (HBV) infection. This case report details the clinical presentation, diagnosis, and management of a 55-year-old male with chronic HBV infection who developed advanced HCC. The patient presented with right upper quadrant pain, weight loss, and jaundice. Diagnostic imaging and biopsy confirmed HCC with portal vein invasion. The patient underwent transarterial chemoembolization (TACE) and was treated with sorafenib. Despite initial response, the disease progressed, and the patient ultimately succumbed to hepatic failure. This case underscores the challenges of managing advanced HCC in patients with cirrhosis and highlights the importance of early detection through regular surveillance in high-risk populations. It also emphasizes the need for a multidisciplinary approach in optimizing outcomes for HCC patients in resource-limited settings like Bangladesh.