Visible-Light Photocatalytic Nucleophilic Addition of 4-Pyridylphosphonium Salts to CO<sub>2</sub> and Carbonyl Compounds
A visible-light photocatalytic nucleophilic addition of 4-pyridylphosphonium salts to CO<sub>2</sub> and carbonyl compounds is reported. The reaction has mild reaction conditions, good functional group tolerance, and a wide range of substrates. Mechanistic studies show that the reaction may occur through the pyridylphosphonium salt radical anion, pyridyl radical, and pyridyl anion intermediates. By combination with C4-H phosphination, this method can be applied to the late-stage C-H functionalization of drugs containing a pyridine unit.
Authors
- Baiquan Wang (ORCID: https://orcid.org/0000-0003-4605-1607)
- Bin Li (ORCID: https://orcid.org/0000-0003-3909-3796)
- Wenwen Cui
Institutions
- Chinese Academy of Sciences (CN)
- Nankai University (CN)
- Shanghai Institute of Organic Chemistry (CN)
- State Key Laboratory of Organometallic Chemistry
Publication Details
- Journal
- Organic Letters
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1021/acs.orglett.5c00786
- Citations
- 7
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 6.55
Funders
- National Natural Science Foundation of China