Clinical Features of Brugada Syndrome Patients With <i>SCN5A</i> Variants
SCN5A pathogenic variants were found to be independent risk factors for cardiac events in BrS patients. Although SCN5A VUS was not an independent risk factor for cardiac events, proportion of symptomatic patients was higher in BrS patients with SCN5A VUS than in those without SCN5A variants. In BrS patients with SCN5A VUS, the signal-averaged ECG was the key to the risk stratification for cardiac events.
Authors
- Yousaku Okubo (ORCID: https://orcid.org/0000-0003-4034-5356)
- Shunsuke Miyauchi (ORCID: https://orcid.org/0000-0001-5781-3182)
- Naoto Oguri (ORCID: https://orcid.org/0000-0002-3345-4274)
- Sho Okamura (ORCID: https://orcid.org/0000-0002-9512-9506)
- Motoki Furutani
- Mika Nakashima
- Takehito Tokuyama (ORCID: https://orcid.org/0000-0003-2722-6934)
- Yukimi Uotani (ORCID: https://orcid.org/0000-0001-9873-3568)
- Takumi Sakai
- Yukiko Nakano
- Rie Akiyama
- Shogo Miyamoto
- Yasuki Kihara
- Hidenori Ochi
Institutions
- Hiroshima University (JP)
- Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital (JP)
- Kobe City Medical Center General Hospital (JP)
Publication Details
- Journal
- Journal of Cardiovascular Electrophysiology
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1111/jce.16643
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00