Dialkylation of Alkenes to Fluorinated δ-Lactams Enabled by Nickel-Electron-Shuttle Catalysis

The δ-lactam motif is a privileged pharmacophore in drug design and development. While these biologically relevant molecules could be assembled through two-component cyclization, a modular approach to constructing these structures via a multicomponent reaction with unactivated alkenes as starting materials is rare. Herein, we report a tandem reaction that integrates alkene-dialkylation with radical-involved ring-opening and cyclization under a single metal-electron-shuttle catalysis, which represents the most expeditious access to fluorinated δ-lactams from unactivated simple alkenes.