回音壁微腔协同的表面增强拉曼散射生物传感

Abstract Surface-enhanced Raman scattering (SERS) technology is a highly sensitive selective and non-destructive spectroscopic analysis method that effectively addresses the challenge of weak Raman scattering signals.Over the past few decades significant progress has been made in SERS biosensing technology including the understanding of enhancement mechanisms development of enhancement materials preparation of high-performance substrates and the creation of nov el SERS detection technologies and equipment.However the design and preparation of high-performance SERS sub strates and the development of novel SERS detection technologies remain necessary to achieve quantitative biosensing and the identification of complex substances.Whispering gallery mode (WGM) optical microcavities can significantly enhance the interaction between the light field and matter within the cavity.The combination of WGM microcavity and SERS tech nology can give full play to the synergistic coupling advantages of WGM effect and SERS effect and it is expected to real ize the double enhancement of Raman scattering.In this paper the SERS enhanced mechanism was elaborated from elec tromagnetic field enhancement chemical enhancement and their synergistic enhancement.The SERS enhanced mecha nism of semiconductor materials and metal-semiconductor composite system was analyzed with zinc oxide (ZnO) as the representative.The SERS synergism in optical resonator system was discussed and the recent research progress of WGM microcavity in synergistically enhancing SERS biosensing was reviewed.