New polyketides from the mangrove-associated endophytic fungus <i>Phomopsis</i> sp. DHS-11
Chemical investigation of the mangrove-derived fungus <i>Phomopsis</i> sp. DHS-11 led to the isolation of three new pyrone derivatives (<b>1</b>-<b>3</b>), and a new natural product (<b>4</b>). Their structures were identified by NMR spectroscopy and mass spectrometry. The configurations for the new pyrone derivatives were tentatively solved by comparison of <sup>13</sup>C NMR data and analysis of the coupling constants and NOESY correlations. Compounds <b>2</b> and <b>3</b> exhibited significant cytotoxicity against HepG2 with IC<sub>50</sub> values of 4.66 ± 0.35 µM and 6.07 ± 0.48 µM, respectively. Compound <b>3</b> showed moderate cytotoxicity against Hela cells with IC<sub>50</sub> value of 20.2 ± 4.93 µM.
Authors
- Xiaoling Deng (ORCID: https://orcid.org/0000-0001-9163-7194)
- Jing Xu (ORCID: https://orcid.org/0000-0002-6201-5318)
- Dandan Chen (ORCID: https://orcid.org/0000-0003-0918-7337)
- Zhi‐Kai Guo
- Bi-Ting Chen
Institutions
- Chinese Academy of Tropical Agricultural Sciences (CN)
- Hainan University (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1080/10286020.2025.2482069
- Citations
- 2
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- National Natural Science Foundation of China