Endurance exercise with reduced muscle glycogen content influences substrate utilization and attenuates acute mTORC1- and autophagic signaling in human type I and type II muscle fibers
Starting an endurance exercise session with low glycogen availability leads to profound changes in substrate utilization in both type I and type II fibers. This may reduce the mTORC1 signaling response, primarily in type I muscle fibers, and attenuate the normally observed reduction in autophagy.
Authors
- Antonio Checa (ORCID: https://orcid.org/0000-0002-0674-3329)
- Jorge L. Ruas (ORCID: https://orcid.org/0000-0002-1110-2606)
- L Cornet (ORCID: https://orcid.org/0009-0009-1282-1205)
- Oscar Horwath (ORCID: https://orcid.org/0000-0002-3500-2896)
- Eva Blomstrand (ORCID: https://orcid.org/0000-0002-6537-042X)
- Karin Söderlund (ORCID: https://orcid.org/0000-0001-5885-2378)
- Marcus Moberg (ORCID: https://orcid.org/0000-0003-3747-0148)
- Sebastian Edman (ORCID: https://orcid.org/0000-0003-2921-833X)
- Henrik Strömlind
Institutions
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- Stanley Medical Research Institute (US)
- Swedish School of Sport and Health Sciences (SE)
Publication Details
- Journal
- Skeletal Muscle
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1186/s13395-025-00377-3
- Citations
- 3
- Primary Topic
- Muscle metabolism and nutrition
- Type
- article
- Field-Weighted Citation Impact
- 3.45