A Genome-Wide Synthetic Lethal Screen Identifies Spermidine Synthase as a Target to Enhance Erdafitinib Efficacy in FGFR-Mutant Bladder Cancer
Combined inhibition of polyamine metabolism and FGFR is a promising therapeutic strategy to overcome erdafitinib resistance and improve treatment for patients with FGFR-mutant bladder cancer.
Authors
- Huayuan Zhao
- Chao Huang (ORCID: https://orcid.org/0009-0004-9219-0696)
- Xincheng Gao (ORCID: https://orcid.org/0000-0002-9061-5812)
- Guosong Jiang (ORCID: https://orcid.org/0000-0002-2766-5016)
- Junping Li
- Hui Zhang (ORCID: https://orcid.org/0000-0001-7531-2525)
- Xingyuan Xiao
- Yanchao Yu
- Jiayin Sun (ORCID: https://orcid.org/0009-0009-1544-5735)
- Xing Xiong
- Miao Wang (ORCID: https://orcid.org/0000-0003-0802-996X)
Institutions
- Jinan University (CN)
- Wuhan University (CN)
- Zhongnan Hospital of Wuhan University (CN)
- Wuhan Union Hospital (CN)
- Shenzhen Luohu People's Hospital (CN)
- Guangdong Provincial People's Hospital (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3217
- Citations
- 4
- Primary Topic
- Polyamine Metabolism and Applications
- Type
- article
- Field-Weighted Citation Impact
- 3.22