SLC3A2-Mediated Lysine Uptake by Cancer Cells Restricts T-cell Activity in Hepatocellular Carcinoma
Hepatocellular carcinoma cells impair T-cell activity by consuming lysine, which can be targeted with SLC3A2 inhibition or lysine supplementation as a therapeutic strategy to enhance antitumor immunity and treatment efficacy.
Authors
- Xiaoxuan Huang (ORCID: https://orcid.org/0009-0005-3029-7188)
- Zilong Xu (ORCID: https://orcid.org/0009-0001-5619-5834)
- Shaopeng Li (ORCID: https://orcid.org/0000-0002-4371-3014)
- Yanhua Lin (ORCID: https://orcid.org/0009-0000-0184-0755)
- Yating Chang (ORCID: https://orcid.org/0009-0009-6536-8504)
- Yueting Liao
- Chaolong Lin
- Chenghao Huang (ORCID: https://orcid.org/0000-0001-8267-1307)
- Naizhen Wang
- Pingguo Liu (ORCID: https://orcid.org/0000-0001-7177-7333)
- Ningshao Xia (ORCID: https://orcid.org/0000-0003-0179-5266)
- Hongning Wu (ORCID: https://orcid.org/0000-0003-2375-5652)
- Jiaqi Zhang (ORCID: https://orcid.org/0000-0002-9740-5148)
- Jun Zhang (ORCID: https://orcid.org/0000-0002-6601-9180)
- Jun Chen
- Y. V. N. Rao
- Lu Li (ORCID: https://orcid.org/0009-0008-0565-0180)
Institutions
- Xiamen University (CN)
- FuelCell Energy (United States) (US)
- Zhongshan Hospital of Xiamen University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3180
- Citations
- 12
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 9.67