Bone mineral density and microarchitecture improvement in a young patient with Hajdu-Cheney syndrome and autosomal dominant polycystic kidney disease treated with alendronate
This case highlights the effectiveness of alendronate in managing osteoporosis in a patient with HCS and ADPKD, despite the current lack of strong supportive evidence. Long-term monitoring revealed substantial improvements in bone density and microarchitecture, underscoring the importance of early diagnosis and intervention for genetic causes of osteoporosis to prevent fracture-related morbidity.
Authors
- Elieser Hitoshi Watanabe (ORCID: https://orcid.org/0000-0002-3371-6019)
- André Silva Franco (ORCID: https://orcid.org/0000-0002-6526-0140)
- Luiz F. Onuchic (ORCID: https://orcid.org/0000-0002-4053-5419)
- Valéria F. Caparbo (ORCID: https://orcid.org/0000-0002-6606-8628)
- Rosa Maria Rodrigues Pereira (ORCID: https://orcid.org/0000-0002-5914-4530)
Institutions
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
Publication Details
- Journal
- Bone Reports
- Published
- 2025-03-24
- DOI
- https://doi.org/10.1016/j.bonr.2025.101838
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00